Immunosuppressive effect of tacrolimus (FK-506): Bone xenografts in rabbits
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چکیده
منابع مشابه
Maculopathy Associated with Tacrolimus (FK 506)
A 63-year-old man with a history of liver transplantation presented to our clinic complaining of visual disturbance. He had been receiving tacrolimus (FK 506) for 30 months (6 mg/day for 2 years and 3 mg/day for 6 months); he reported that the visual disturbance began while taking tacrolimus. A full ophthalmologic examination and electrophysiologic and imaging studies were performed. The best c...
متن کاملFK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.
The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and...
متن کاملTacrolimus ( FK 506 ) and the Pharmaceuticall Academid Regulatory Gauntlet
• The pivotal Issue of transplant rejection diagnosis and management Is design, conduct, and analysis of clinical trials. The historical experience with clinical trials of major immunosuppressive drugs (cyclosporine and especially tacrollmus) Is examined in this article. Cyclosporlne was a turning point In transplantation, providing an extraordinary Improvement over previous therapies. Addition...
متن کاملImmunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporine A.
R ECENT STUDIES have described a new potent immunosuppressive drug FK-506 (FK) that induces considerable prolongation of allograft survival.'·) This drug is isolated from Streptomyces tsukubaensis. has a molecular weight of 822 daltons, and is structurally different from cyclosporine A (CsA). In vitro investigations have demonstrated a strong inhibitory effect on lymphocyte activation that appe...
متن کاملIntra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm
Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus),a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages oflearning and memory the main aim of this study was t...
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ژورنال
عنوان ژورنال: Acta Orthopaedica Scandinavica
سال: 1996
ISSN: 0001-6470
DOI: 10.3109/17453679609002337